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Heparanase-2 protects from LPS-mediated endothelial injury by inhibiting TLR4 signalling
The endothelial glycocalyx and its regulated shedding are important to vascular health. Endo-β-D-glucuronidase heparanase-1 (HPSE1) is the only enzyme that can shed heparan sulfate. However, the mechanisms are not well understood. We show that HPSE1 activity aggravated Toll-like receptor 4 (TLR4)-me...
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| Publié dans: | Sci Rep |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6753096/ https://ncbi.nlm.nih.gov/pubmed/31537875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50068-5 |
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