CHK1 and RAD51 activation after DNA damage is regulated via urokinase receptor/TLR4 signaling

Mechanisms of DNA damage and repair signaling are not completely understood that hinder the efficiency of cancer therapy. Urokinase-type plasminogen activator receptor (PLAUR) is highly expressed in most solid cancers and serves as a marker of poor prognosis. We show that PLAUR actively promotes DNA...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Narayanaswamy, Pavan B, Tkachuk, Sergey, Haller, Hermann, Dumler, Inna, Kiyan, Yulia
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059885/
https://ncbi.nlm.nih.gov/pubmed/27685627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.291
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