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Reverse gene-environment interaction approach to identify variants influencing body-mass index in humans

Identifying gene-environment interactions (GxEs) contributing to human cardiometabolic disorders is challenging. Here we apply a reverse GxE candidate search by deriving candidate variants from promoter-enhancer interactions that respond to dietary fatty acid challenge through altered chromatin acce...

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Detalhes bibliográficos
Publicado no:Nat Metab
Main Authors: Garske, Kristina M., Pan, David Z., Miao, Zong, Bhagat, Yash V., Comenho, Caroline, Robles, Christopher R., Benhammou, Jihane N., Alvarez, Marcus, Ko, Arthur, Ye, Chun Jimmie, Pisegna, Joseph R., Mohlke, Karen L., Sinsheimer, Janet S., Laakso, Markku, Pajukanta, Päivi
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6752726/
https://ncbi.nlm.nih.gov/pubmed/31538139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-019-0071-6
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