LMO2 confers synthetic lethality to PARP inhibition in DLBCL

Deficiency in DNA double-strand break (DSB) repair mechanisms has been widely exploited for the treatment of different malignances, including homologous recombination (HR)-deficient breast and ovarian cancers. Here we demonstrate that diffuse large B cell lymphomas (DLBCL) expressing LMO2 protein ar...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Cell
Prif Awduron: Parvin, Salma, Ramirez-Labrada, Ariel, Aumann, Shlomzion, Lu, XiaoQing, Weich, Natalia, Santiago, Gabriel, Cortizas, Elena M., Sharabi, Eden, Zhang, Yu, Sanchez-Garcia, Isidro, Gentles, Andrew J., Roberts, Evan, Cortes, Daniel Bilbao, Vega, Francisco, Chapman, Jennifer R., Verdun, Ramiro E., Lossos, Izidore S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6752209/
https://ncbi.nlm.nih.gov/pubmed/31447348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.07.007
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