Null Mutation of the Lmo4 Gene or a Combined Null Mutation of the Lmo1/Lmo3 Genes Causes Perinatal Lethality, and Lmo4 Controls Neural Tube Development in Mice

The LIM-only family of proteins comprises four members; two of these (LMO1 and LMO2) are involved in human T-cell leukemia via chromosomal translocations, and LMO2 is a master regulator of hematopoiesis. We have carried out gene targeting of the other members of the LIM-only family, viz., genes Lmo1...

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Détails bibliographiques
Publié dans:Mol Cell Biol
Auteurs principaux: Tse, E., Smith, A. J. H., Hunt, S., Lavenir, I., Forster, A., Warren, A. J., Grutz, G., Foroni, L., Carlton, M. B. L., Colledge, W. H., Boehm, T., Rabbitts, T. H.
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2004
Sujets:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC350562/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14966285/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.5.2063-2073.2004
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