Suppressing Hedgehog signaling reverses drug resistance of refractory acute myeloid leukemia

BACKGROUND: Hedgehog (Hh) signaling is involved in the pathogenesis of tumors. By performing gene chip analysis, we predicted that Hh signaling might regulate multiple downstream pathways in acute myeloid leukemia (AML). METHODS: In this study, the potential role of the Hh pathway in refractory AML,...

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Detalhes bibliográficos
Publicado no:Onco Targets Ther
Main Authors: Huang, Kaikai, Sun, Zhiqiang, Ding, Bingjie, Jiang, Xuejie, Wang, Zhixiang, Zhu, Yufeng, Meng, Fanyi
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2019
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6752208/
https://ncbi.nlm.nih.gov/pubmed/31686853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S216628
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