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Zein-alpha lipoic acid-loaded nanoparticles to enhance the oral bioavailability of dapoxetine: optimization and clinical pharmacokinetic evaluation

BACKGROUND: Premature ejaculation (PE) is the most common type of male sexual disorder with important psychological consequences. Dapoxetine (DPX), a recently approved drug for the treatment of PE, suffers from low bioavailability with large variability that ranges from 15–76% (mean 42%) after oral...

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Podrobná bibliografie
Vydáno v:Int J Nanomedicine
Hlavní autoři: El-Say, Khalid M, Ahmed, Osama AA, Mohamed, Amir I, Safo, Martin K, Omar, Abdelsattar M
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6752166/
https://ncbi.nlm.nih.gov/pubmed/31686817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S224611
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