Accelerated degradation of cFLIP(L) and sensitization of the TRAIL DISC-mediated apoptotic cascade by pinoresinol, a lignan isolated from Rubia philippinensis

Plant-derived lignans have numerous biological effects including anti-tumor and anti-inflammatory activities. Screening of purified constituents of Rubia philippinensis from human glioblastoma cells resistant to TNF-related apoptosis-inducing ligand (TRAIL) has suggested that the lignan pinoresinol...

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Pubblicato in:Sci Rep
Autori principali: Lee, So-Ra, Quan, Khong Trong, Byun, Hee Sun, Park, InWha, Kang, Kidong, Piao, Xuezhe, Ju, Eunjin, Ro, Hyunju, Na, MinKyun, Hur, Gang Min
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6751165/
https://ncbi.nlm.nih.gov/pubmed/31534206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-49909-0
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