Generation of DelNS1 Influenza Viruses: a Strategy for Optimizing Live Attenuated Influenza Vaccines

Nonstructural protein 1 (NS1) of influenza virus is a key virulence element with multifunctional roles in virus replication and a potent antagonist of host immune response. Deletion of NS1 (DelNS1) would create a safer and more extensively immunogenic live attenuated influenza virus (LAIV) vaccine....

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Publicado en:mBio
Main Authors: Wang, Pui, Zheng, Min, Lau, Siu-Ying, Chen, Pin, Mok, Bobo Wing-Yee, Liu, Siwen, Liu, Honglian, Huang, Xiaofeng, Cremin, Conor J., Song, Wenjun, Chen, Yixin, Wong, Yik-Chun, Huang, Haode, To, Kelvin Kai-Wong, Chen, Zhiwei, Xia, Ningshao, Yuen, Kwok-Yung, Chen, Honglin
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2019
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6751066/
https://ncbi.nlm.nih.gov/pubmed/31530680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02180-19
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