An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells

Influenza virus utilizes host splicing machinery to process viral mRNAs expressed from both M and NS segments. Through genetic analysis and functional characterization, we here show that the NS segment of H7N9 virus contains a unique G540A substitution, located within a previously undefined exonic s...

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Publicat a:Nat Commun
Autors principals: Huang, Xiaofeng, Zheng, Min, Wang, Pui, Mok, Bobo Wing-Yee, Liu, Siwen, Lau, Siu-Ying, Chen, Pin, Liu, Yen-Chin, Liu, Honglian, Chen, Yixin, Song, Wenjun, Yuen, Kwok-Yung, Chen, Honglin
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364394/
https://ncbi.nlm.nih.gov/pubmed/28323816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14751
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