The miR-216a-Dot1l Regulatory Axis Is Necessary and Sufficient for Müller Glia Reprogramming during Retina Regeneration

Unlike the adult mammalian retina, Müller glia (MG) in the adult zebrafish retina are able to dedifferentiate into a ‘‘stem cell’’-like state and give rise to multipotent progenitor cells upon retinal damage. We show that miR-216a is downregulated in MG after constant intense light lesioning and tha...

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Vydáno v:Cell Rep
Hlavní autoři: Kara, Nergis, Kent, Matthew R., Didiano, Dominic, Rajaram, Kamya, Zhao, Anna, Summerbell, Emily R., Patton, James G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6750267/
https://ncbi.nlm.nih.gov/pubmed/31433981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.07.061
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