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Profiling allele specific gene expression in brains from individuals with autism spectrum disorder reveals preferential minor allele usage

One fundamental, but understudied mechanism of gene regulation in disease is allele specific expression (ASE), the preferential expression of one allele. We leveraged RNA-seq from human brain to assess ASE in autism spectrum disorder (ASD). When ASE is observed in ASD, the allele with lower populati...

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Publicado en:Nat Neurosci
Main Authors: Lee, Changhoon, Kang, Eun Yong, Gandal, Michael J., Eskin, Eleazar, Geschwind, Daniel H.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6750256/
https://ncbi.nlm.nih.gov/pubmed/31455884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-019-0461-9
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