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Profiling allele specific gene expression in brains from individuals with autism spectrum disorder reveals preferential minor allele usage
One fundamental, but understudied mechanism of gene regulation in disease is allele specific expression (ASE), the preferential expression of one allele. We leveraged RNA-seq from human brain to assess ASE in autism spectrum disorder (ASD). When ASE is observed in ASD, the allele with lower populati...
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| Опубликовано в: : | Nat Neurosci |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6750256/ https://ncbi.nlm.nih.gov/pubmed/31455884 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-019-0461-9 |
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