Direct Nkx2‐5 Transcriptional Repression of Isl1 Controls Cardiomyocyte Subtype Identity

During cardiogenesis, most myocytes arise from cardiac progenitors expressing the transcription factors Isl1 and Nkx2‐5. Here, we show that a direct repression of Isl1 by Nkx2‐5 is necessary for proper development of the ventricular myocardial lineage. Overexpression of Nkx2‐5 in mouse embryonic ste...

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Pubblicato in:Stem Cells
Autori principali: Dorn, Tatjana, Goedel, Alexander, Lam, Jason T., Haas, Jessica, Tian, Qinghai, Herrmann, Franziska, Bundschu, Karin, Dobreva, Gergana, Schiemann, Matthias, Dirschinger, Ralf, Guo, Yanchun, Kühl, Susanne J., Sinnecker, Daniel, Lipp, Peter, Laugwitz, Karl-Ludwig, Kühl, Michael, Moretti, Alessandra
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2015
Soggetti:
Embryonic Stem Cells/Induced Pluripotent Stem Cells
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6750130/
https://ncbi.nlm.nih.gov/pubmed/25524439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1923
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