Calpain-10 drives podocyte apoptosis and renal injury in diabetic nephropathy

BACKGROUND: Diabetic nephropathy (DN) is a progressive microvascular complication of diabetes mellitus (DM), driven largely by podocyte apoptosis. The cysteine protease Calpain 10 is known to augment apoptosis and necrosis, and is a potential therapeutic target in DN. METHODS: Type 2 diabetes was in...

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Detalhes bibliográficos
Publicado no:Diabetes Metab Syndr Obes
Main Authors: Wang, Tao, Gao, Yanbin, Wang, Xiaolei, Shi, Yimin, Xu, Jiayi, Wu, Bingjie, He, Jiaxin, Li, Yimeng
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2019
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6750010/
https://ncbi.nlm.nih.gov/pubmed/31571956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DMSO.S217924
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