Targeting interferon signaling and CTLA-4 enhance the therapeutic efficacy of anti-PD-1 immunotherapy in preclinical model of HPV(+) oral cancer

BACKGROUND: The US is experiencing an epidemic of HPV(+) oropharyngeal cancers (OPC), the rates and burden of which now exceed that for cervical cancer. Immunotherapy targeting programmed death 1 (PD-1) on tumor-infiltrating lymphocytes and/or its ligand PD-L1 on tumor cells, which was effective in...

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Pubblicato in:J Immunother Cancer
Autori principali: Dorta-Estremera, Stephanie, Hegde, Venkatesh L., Slay, Ravaen B., Sun, Rachel, Yanamandra, Ananta V., Nicholas, Courtney, Nookala, Sita, Sierra, Gloria, Curran, Michael A., Sastry, K. Jagannadha
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6749627/
https://ncbi.nlm.nih.gov/pubmed/31533840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0728-4
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