Preclinical Study of DNA-Recognized Peptide Compound Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Progressive Renal Diseases in the Common Marmoset

Pyrrole-imidazole (PI) polyamides are novel gene silencers that strongly bind the promoter region of target genes in a sequence-specific manner to inhibit gene transcription. We created a PI polyamide targeting human TGF-β1 (hTGF-β1). To develop this PI polyamide targeting hTGF-β1 (Polyamide) as a p...

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Publié dans:Molecules
Auteurs principaux: Otsuki, Masari, Fukuda, Noboru, Inoue, Takashi, Mineshige, Takayuki, Otsuki, Tomoyasu, Horikoshi, Shu, Endo, Morito, Abe, Masanori
Format: Artigo
Langue:Inglês
Publié: MDPI 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6749436/
https://ncbi.nlm.nih.gov/pubmed/31480595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24173178
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