Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Hypertrophic Scars in a Common Marmoset Primate Model

We report a preclinical study of a pyrrole-imidazole (PI) polyamide that targets the human transforming growth factor (hTGF)-β1 gene as a novel transcriptional gene silencer in a common marmoset primate model. We designed and then synthesized PI polyamides to target the hTGF-β1 promoter. We examined...

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Bibliographic Details
Published in:PLoS One
Main Authors: Igarashi, Jun, Fukuda, Noboru, Inoue, Takashi, Nakai, Shigeki, Saito, Kosuke, Fujiwara, Kyoko, Matsuda, Hiroyuki, Ueno, Takahiro, Matsumoto, Yoshiaki, Watanabe, Takayoshi, Nagase, Hiroki, Bando, Toshikazu, Sugiyama, Hiroshi, Itoh, Toshio, Soma, Masayoshi
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4418757/
https://ncbi.nlm.nih.gov/pubmed/25938472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0125295
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