Synthesis of Novel 2-(Het)arylpyrrolidine Derivatives and Evaluation of Their Anticancer and Anti-Biofilm Activity

A library of novel 2-(het)arylpyrrolidine-1-carboxamides were obtained via a modular approach based on the intramolecular cyclization/Mannich-type reaction of N-(4,4-diethoxybutyl)ureas. Their anti-cancer activities both in vitro and in vivo were tested. The in vitro activity of some compounds towar...

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Udgivet i:Molecules
Main Authors: Smolobochkin, Andrey, Gazizov, Almir, Sazykina, Marina, Akylbekov, Nurgali, Chugunova, Elena, Sazykin, Ivan, Gildebrant, Anastasiya, Voronina, Julia, Burilov, Alexander, Karchava, Shorena, Klimova, Maria, Voloshina, Alexandra, Sapunova, Anastasia, Klimanova, Elena, Sashenkova, Tatyana, Allayarova, Ugulzhan, Balakina, Anastasiya, Mishchenko, Denis
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6749236/
https://ncbi.nlm.nih.gov/pubmed/31450696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24173086
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