The Obese Liver Environment Mediates Conversion of NK Cells to a Less Cytotoxic ILC1-Like Phenotype

The liver contains both NK cells and their less cytotoxic relatives, ILC1. Here, we investigate the role of NK cells and ILC1 in the obesity-associated condition, non-alcoholic fatty liver disease (NAFLD). In the livers of mice suffering from NAFLD, NK cells are less able to degranulate, express low...

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Vydáno v:Front Immunol
Hlavní autoři: Cuff, Antonia O., Sillito, Francesca, Dertschnig, Simone, Hall, Andrew, Luong, Tu Vinh, Chakraverty, Ronjon, Male, Victoria
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6749082/
https://ncbi.nlm.nih.gov/pubmed/31572388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02180
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