The Obese Liver Environment Mediates Conversion of NK Cells to a Less Cytotoxic ILC1-Like Phenotype

The liver contains both NK cells and their less cytotoxic relatives, ILC1. Here, we investigate the role of NK cells and ILC1 in the obesity-associated condition, non-alcoholic fatty liver disease (NAFLD). In the livers of mice suffering from NAFLD, NK cells are less able to degranulate, express low...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Cuff, Antonia O., Sillito, Francesca, Dertschnig, Simone, Hall, Andrew, Luong, Tu Vinh, Chakraverty, Ronjon, Male, Victoria
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6749082/
https://ncbi.nlm.nih.gov/pubmed/31572388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02180
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