Pseudovirus rVSVΔG-ZEBOV-GP Infects Neurons in Retina and CNS, Causing Apoptosis and Neurodegeneration in Neonatal Mice

Zaire Ebola virus (ZEBOV) survivors experience visual and CNS sequelae that suggests the ZEBOV glycoprotein can mediate neurotropism. Replication-competent rVSVΔG-ZEBOV-GP vaccine candidate is generally well tolerated; however, its potential neurotropism requires careful study. Here, we show that a...

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Gepubliceerd in:Cell Rep
Hoofdauteurs: McWilliams, Ian L., Kielczewski, Jennifer L., Ireland, Derek D.C., Sykes, Jacob S., Lewkowicz, Aaron P., Konduru, Krishnamurthy, Xu, Biying C., Chan, Chi-Chao, Caspi, Rachel R., Manangeeswaran, Mohanraj, Verthelyi, Daniela
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748882/
https://ncbi.nlm.nih.gov/pubmed/30759384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.01.069
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