Pseudovirus rVSVΔG-ZEBOV-GP Infects Neurons in Retina and CNS, Causing Apoptosis and Neurodegeneration in Neonatal Mice

Zaire Ebola virus (ZEBOV) survivors experience visual and CNS sequelae that suggests the ZEBOV glycoprotein can mediate neurotropism. Replication-competent rVSVΔG-ZEBOV-GP vaccine candidate is generally well tolerated; however, its potential neurotropism requires careful study. Here, we show that a...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: McWilliams, Ian L., Kielczewski, Jennifer L., Ireland, Derek D.C., Sykes, Jacob S., Lewkowicz, Aaron P., Konduru, Krishnamurthy, Xu, Biying C., Chan, Chi-Chao, Caspi, Rachel R., Manangeeswaran, Mohanraj, Verthelyi, Daniela
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748882/
https://ncbi.nlm.nih.gov/pubmed/30759384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.01.069
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