Mechanisms of iron- and O(2)-sensing by the [4Fe-4S] cluster of the global iron regulator RirA

RirA is a global regulator of iron homeostasis in Rhizobium and related α-proteobacteria. In its [4Fe-4S] cluster-bound form it represses iron uptake by binding to IRO Box sequences upstream of RirA-regulated genes. Under low iron and/or aerobic conditions, [4Fe-4S] RirA undergoes cluster conversion...

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Bibliographic Details
Published in:eLife
Main Authors: Pellicer Martinez, Ma Teresa, Crack, Jason C, Stewart, Melissa YY, Bradley, Justin M, Svistunenko, Dimitri A, Johnston, Andrew WB, Cheesman, Myles R, Todd, Jonathan D, Le Brun, Nick E
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2019
Subjects:
Biochemistry and Chemical Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748827/
https://ncbi.nlm.nih.gov/pubmed/31526471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47804
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