MIR-144-mediated NRF2 gene silencing inhibits fetal hemoglobin expression in sickle cell disease

Inherited genetic modifiers and pharmacologic agents that enhance fetal hemoglobin (HbF) expression reverse the clinical severity of sickle cell disease (SCD). Recent efforts to develop novel strategies of HbF induction include discovery of molecular targets that regulate γ-globin gene transcription...

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Bibliografske podrobnosti
izdano v:Exp Hematol
Main Authors: Li, Biaoru, Zhu, Xingguo, Ward, Christina M., Starlard-Davenport, Athena, Takezaki, Mayuko, Berry, Amber, Ward, Alexander, Wilder, Caroline, Neunert, Cindy, Kutlar, Abdullah, Pace, Betty S.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748328/
https://ncbi.nlm.nih.gov/pubmed/30412705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2018.11.002
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