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MIR-144-mediated NRF2 gene silencing inhibits fetal hemoglobin expression in sickle cell disease
Inherited genetic modifiers and pharmacologic agents that enhance fetal hemoglobin (HbF) expression reverse the clinical severity of sickle cell disease (SCD). Recent efforts to develop novel strategies of HbF induction include discovery of molecular targets that regulate γ-globin gene transcription...
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| Publicado no: | Exp Hematol |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6748328/ https://ncbi.nlm.nih.gov/pubmed/30412705 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2018.11.002 |
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