Hyperglycemia-Induced Oxidative Stress Abrogates Remifentanil Preconditioning-Mediated Cardioprotection in Diabetic Rats by Impairing Caveolin-3-Modulated PI3K/Akt and JAK2/STAT3 Signaling

Diabetic hearts are more vulnerable to ischemia/reperfusion (I/R) injury and less responsive to remifentanil preconditioning (RPC), but the underlying mechanisms are incompletely understood. Caveolin-3 (Cav-3), the dominant isoform of cardiomyocyte caveolae, is reduced in diabetic hearts in which ox...

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Опубликовано в: :Oxid Med Cell Longev
Главные авторы: Lei, Shaoqing, Su, Wating, Xia, Zhong-Yuan, Wang, Yafeng, Zhou, Lu, Qiao, Shigang, Zhao, Bo, Xia, Zhengyuan, Irwin, Michael G.
Формат: Artigo
Язык:Inglês
Опубликовано: Hindawi 2019
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748204/
https://ncbi.nlm.nih.gov/pubmed/31583053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/9836302
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