The RNA binding protein Sam68 controls T helper 1 differentiation and anti-mycobacterial response through modulation of miR-29

Polarization of naive T cells into interferon (IFN)-γ-producing T helper 1 (Th1) cells is an essential event in the inflammatory response to pathogens. Herein, we identify the RNA binding protein Sam68 as a specific modulator of Th1 differentiation. Sam68-knockout (ko) naive T cells are strongly def...

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Vydáno v:Cell Death Differ
Hlavní autoři: Volpe, Elisabetta, Cesari, Eleonora, Mercatelli, Neri, Cicconi, Rosella, De Bardi, Marco, Capone, Alessia, Bonvissuto, Davide, Fraziano, Maurizio, Mattei, Maurizio, Battistini, Luca, Paronetto, Maria Paola, Sette, Claudio
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748099/
https://ncbi.nlm.nih.gov/pubmed/30258098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0201-9
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