STING directly activates autophagy to tune the innate immune response

STING (stimulator of interferon genes) is a central molecule that binds to cyclic dinucleotides produced by the cyclic GMP-AMP synthase (cGAS) to activate innate immunity against microbial infection. Here we report that STING harbors classic LC-3 interacting regions (LIRs) and mediates autophagy thr...

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Bibliografske podrobnosti
izdano v:Cell Death Differ
Main Authors: Liu, Dong, Wu, Hao, Wang, Chenguang, Li, Yanjun, Tian, Huabin, Siraj, Sami, Sehgal, Sheikh Arslan, Wang, Xiaohui, Wang, Jun, Shang, Yingli, Jiang, Zhengfan, Liu, Lei, Chen, Quan
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748081/
https://ncbi.nlm.nih.gov/pubmed/30568238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0251-z
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