CXCR5(+)PD1(+)ICOS(+) Circulating T Follicular Helpers Are Associated With de novo Donor-Specific Antibodies After Renal Transplantation

Donor-specific anti-HLA antibodies (DSAs) are a major risk factor associated with renal allograft outcomes. As a trigger of B cell antibody production, T follicular helper cells (Tfhs) promote DSA appearance. Herein, we evaluated whether circulating Tfhs (cTfhs) are associated with the genesis of an...

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Vydáno v:Front Immunol
Hlavní autoři: Danger, Richard, Chesneau, Mélanie, Delbos, Florent, Le Bot, Sabine, Kerleau, Clarisse, Chenouard, Alexis, Ville, Simon, Degauque, Nicolas, Conchon, Sophie, Cesbron, Anne, Giral, Magali, Brouard, Sophie
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746839/
https://ncbi.nlm.nih.gov/pubmed/31552030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02071
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