Direct comparison of target-reactivity and cross-reactivity induced by CAR- and BiTE-redirected T cells for the development of antibody-based T-cell therapy

The development of chimeric antigen receptor (CAR) and bispecific T-cell engager (BiTE) has led to the successful application of cancer immunotherapy. The potential reactivity mediated by CAR- and BiTE-redirected T cells needs to be assessed to facilitate the application of these treatment options t...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Maruta, Masaki, Ochi, Toshiki, Tanimoto, Kazushi, Asai, Hiroaki, Saitou, Takashi, Fujiwara, Hiroshi, Imamura, Takeshi, Takenaka, Katsuto, Yasukawa, Masaki
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746725/
https://ncbi.nlm.nih.gov/pubmed/31527633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-49834-2
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