Overexpression of hsa-miR-186 induces chromosomal instability in arsenic-exposed human keratinocytes

The mechanism of arsenic-induced skin carcinogenesis is not yet fully understood. Chromosomal instability contributes to aneuploidy and is a driving force in carcinogenesis. Arsenic causes mitotic arrest and induces aneuploidy. hsa-miR-186 overexpression is associated with metastatic cancers as well...

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Publicado no:Toxicol Appl Pharmacol
Main Authors: Wu, Jiguo, Ferragut Cardoso, Ana P., States, Vanessa A. R., Al-Eryani, Laila, Doll, Mark, Wise, Sandra S., Rai, Shesh N., States, J. Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746570/
https://ncbi.nlm.nih.gov/pubmed/31176655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2019.114614
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