C-terminal proteolysis of the collagen VI α3 chain by BMP-1 and proprotein convertase(s) releases endotrophin in fragments of different sizes

The assembly of collagen VI microfibrils is a multistep process in which proteolytic processing within the C-terminal globular region of the collagen VI α3 chain plays a major role. However, the mechanisms involved remain elusive. Moreover, C5, the short and most C-terminal domain of the α3 chain, r...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Heumüller, Stefanie Elisabeth, Talantikite, Maya, Napoli, Manon, Armengaud, Jean, Mörgelin, Matthias, Hartmann, Ursula, Sengle, Gerhard, Paulsson, Mats, Moali, Catherine, Wagener, Raimund
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Glycobiology and Extracellular Matrices
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746452/
https://ncbi.nlm.nih.gov/pubmed/31346034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008641
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