Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells

Despite advances in the differentiation of insulin-producing cells from human embryonic stem cells, the generation of mature functional β cells in vitro has remained elusive. To accomplish this goal, we have developed cell culture conditions to closely mimic events occurring during pancreatic islet...

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發表在:Nat Cell Biol
Main Authors: Nair, Gopika G., Liu, Jennifer S., Russ, Holger A., Tran, Stella, Saxton, Michael S., Chen, Richard, Juang, Charity, Li, Mei-lan, Nguyen, Vinh Q., Giacometti, Simone, Puri, Sapna, Xing, Yuan, Wang, Yong, Szot, Gregory L., Oberholzer, Jose, Bhushan, Anil, Hebrok, Matthias
格式: Artigo
語言:Inglês
出版: 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746427/
https://ncbi.nlm.nih.gov/pubmed/30710150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0271-4
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