Towards discovery of novel scaffold with potent antiangiogenic activity; design, synthesis of pyridazine based compounds, impact of hinge interaction, and accessibility of their bioactive conformation on VEGFR-2 activities

Lignende værker

• Design and synthesis of phthalazine-based compounds as potent anticancer agents with potential antiangiogenic activity via VEGFR-2 inhibition
  af: Elmeligie, Salwa, et al.
  Udgivet: (2019)
• Discovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting Agents
  af: Aziz, Marwa A., et al.
  Udgivet: (2016)
• Development of Potent Adenosine Monophosphate-Activated Protein Kinase Activators
  af: Dokla, Eman M. E., et al.
  Udgivet: (2015)
• YLT192, a Novel, Orally Active Bioavailable Inhibitor of VEGFR2 Signaling with Potent Antiangiogenic Activity and Antitumor Efficacy in Preclinical Models
  af: Xia, Yong, et al.
  Udgivet: (2014)
• In vitro and in vivo antiangiogenic activity of desacetylvinblastine monohydrazide through inhibition of VEGFR2 and Axl pathways
  af: Lei, Xueping, et al.
  Udgivet: (2016)