Conditional deletion of melanin-concentrating hormone receptor 1 from GABAergic neurons increases locomotor activity

OBJECTIVE: Melanin-concentrating hormone (MCH) plays a key role in regulating energy balance. MCH acts via its receptor MCHR1, and MCHR1 deletion increases energy expenditure and locomotor activity, which is associated with a hyperdopaminergic state. Since MCHR1 expression is widespread, the neurons...

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Detalles Bibliográficos
Publicado en:Mol Metab
Main Authors: Chee, Melissa J., Hebert, Alex J., Briançon, Nadege, Flaherty, Stephen E., Pissios, Pavlos, Maratos-Flier, Eleftheria
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2019
Assuntos:
Brief Communication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6745487/
https://ncbi.nlm.nih.gov/pubmed/31668382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2019.08.018
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