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On the use of interaction energies in QM/MM free energy simulations

The use of the most accurate (i.e., QM or QM/MM) levels of theory for free energy simulations (FES) is typically not possible. Primarily, this is because the computational cost associated with the extensive configurational sampling needed for converging FES is prohibitive. To ensure the feasibility...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Chem Theory Comput
Prif Awduron: Hudson, Phillip S., Woodcock, H. Lee, Boresch, Stefan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6745021/
https://ncbi.nlm.nih.gov/pubmed/31142113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jctc.9b00084
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