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The Good, the Bad, and the Ugly: “HiPen”, a New Dataset for Validating (S)QM/MM Free Energy Simulations

Indirect (S)QM/MM free energy simulations (FES) are vital to efficiently incorporating sufficient sampling and accurate (QM) energetic evaluations when estimating free energies of practical/experimental interest. Connecting between levels of theory, i.e., calculating [Formula: see text] , remains to...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Kearns, Fiona L., Warrensford, Luke, Boresch, Stefan, Woodcock, H. Lee
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413162/
https://ncbi.nlm.nih.gov/pubmed/30769826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24040681
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