Allosteric modulation of β-cell M(3) muscarinic acetylcholine receptors greatly improves glucose homeostasis in lean and obese mice

Given the global epidemic in type 2 diabetes, novel antidiabetic drugs with increased efficacy and reduced side effects are urgently needed. Previous work has shown that M(3) muscarinic acetylcholine (ACh) receptors (M3Rs) expressed by pancreatic β cells play key roles in stimulating insulin secreti...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zhu, Lu, Rossi, Mario, Cohen, Amanda, Pham, Jonathan, Zheng, Hongchao, Dattaroy, Diptadip, Mukaibo, Taro, Melvin, James E., Langel, Jennifer L., Hattar, Samer, Matschinsky, Franz M., Appella, Daniel H., Doliba, Nicolai M., Wess, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744902/
https://ncbi.nlm.nih.gov/pubmed/31451647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904943116
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