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Predictive shifts in free energy couple mutations to their phenotypic consequences
Mutation is a critical mechanism by which evolution explores the functional landscape of proteins. Despite our ability to experimentally inflict mutations at will, it remains difficult to link sequence-level perturbations to systems-level responses. Here, we present a framework centered on measuring...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6744869/ https://ncbi.nlm.nih.gov/pubmed/31451655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1907869116 |
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