The nuclear receptor REV-ERBα modulates Th17 cell-mediated autoimmune disease

T helper 17 (Th17) cells produce interleukin-17 (IL-17) cytokines and drive inflammatory responses in autoimmune diseases such as multiple sclerosis. The differentiation of Th17 cells is dependent on the retinoic acid receptor-related orphan nuclear receptor RORγt. Here, we identify REV-ERBα (encode...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Chang, Christina, Loo, Chin-San, Zhao, Xuan, Solt, Laura A., Liang, Yuqiong, Bapat, Sagar P., Cho, Han, Kamenecka, Theodore M., Leblanc, Mathias, Atkins, Annette R., Yu, Ruth T., Downes, Michael, Burris, Thomas P., Evans, Ronald M., Zheng, Ye
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2019
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744854/
https://ncbi.nlm.nih.gov/pubmed/31455731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1907563116
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