The nuclear receptor REV-ERBα modulates Th17 cell-mediated autoimmune disease

T helper 17 (Th17) cells produce interleukin-17 (IL-17) cytokines and drive inflammatory responses in autoimmune diseases such as multiple sclerosis. The differentiation of Th17 cells is dependent on the retinoic acid receptor-related orphan nuclear receptor RORγt. Here, we identify REV-ERBα (encode...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Chang, Christina, Loo, Chin-San, Zhao, Xuan, Solt, Laura A., Liang, Yuqiong, Bapat, Sagar P., Cho, Han, Kamenecka, Theodore M., Leblanc, Mathias, Atkins, Annette R., Yu, Ruth T., Downes, Michael, Burris, Thomas P., Evans, Ronald M., Zheng, Ye
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744854/
https://ncbi.nlm.nih.gov/pubmed/31455731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1907563116
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