The nuclear receptor REV-ERBα modulates Th17 cell-mediated autoimmune disease

T helper 17 (Th17) cells produce interleukin-17 (IL-17) cytokines and drive inflammatory responses in autoimmune diseases such as multiple sclerosis. The differentiation of Th17 cells is dependent on the retinoic acid receptor-related orphan nuclear receptor RORγt. Here, we identify REV-ERBα (encode...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Chang, Christina, Loo, Chin-San, Zhao, Xuan, Solt, Laura A., Liang, Yuqiong, Bapat, Sagar P., Cho, Han, Kamenecka, Theodore M., Leblanc, Mathias, Atkins, Annette R., Yu, Ruth T., Downes, Michael, Burris, Thomas P., Evans, Ronald M., Zheng, Ye
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744854/
https://ncbi.nlm.nih.gov/pubmed/31455731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1907563116
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