RhoBTB1 interacts with ROCKs and inhibits invasion

RhoBTB1 is an atypical Rho GTPase with two BTB domains in addition to its Rho domain. Although most Rho GTPases regulate actin cytoskeletal dynamics, RhoBTB1 is not known to affect cell shape or motility. We report that RhoBTB1 depletion increases prostate cancer cell invasion and induces elongation...

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Dettagli Bibliografici
Pubblicato in:Biochem J
Autori principali: Haga, Raquel B., Garg, Ritu, Collu, Francesca, Borda D'Agua, Bárbara, Menéndez, Sofia T., Colomba, Audrey, Fraternali, Franca, Ridley, Anne J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Portland Press Ltd. 2019
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744581/
https://ncbi.nlm.nih.gov/pubmed/31431478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20190203
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