RhoBTB1 interacts with ROCKs and inhibits invasion

RhoBTB1 is an atypical Rho GTPase with two BTB domains in addition to its Rho domain. Although most Rho GTPases regulate actin cytoskeletal dynamics, RhoBTB1 is not known to affect cell shape or motility. We report that RhoBTB1 depletion increases prostate cancer cell invasion and induces elongation...

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Bibliografiske detaljer
Udgivet i:Biochem J
Main Authors: Haga, Raquel B., Garg, Ritu, Collu, Francesca, Borda D'Agua, Bárbara, Menéndez, Sofia T., Colomba, Audrey, Fraternali, Franca, Ridley, Anne J.
Format: Artigo
Sprog:Inglês
Udgivet: Portland Press Ltd. 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744581/
https://ncbi.nlm.nih.gov/pubmed/31431478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20190203
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