Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites

The centrosome is the master orchestrator of mitotic spindle formation and chromosome segregation in animal cells. Centrosome abnormalities are frequently observed in cancer, but little is known of their origin and about pathways affecting centrosome homeostasis. Here we show that autophagy preserve...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Holdgaard, Søs Grønbæk, Cianfanelli, Valentina, Pupo, Emanuela, Lambrughi, Matteo, Lubas, Michal, Nielsen, Julie C., Eibes, Susana, Maiani, Emiliano, Harder, Lea M., Wesch, Nicole, Foged, Mads Møller, Maeda, Kenji, Nazio, Francesca, de la Ballina, Laura R., Dötsch, Volker, Brech, Andreas, Frankel, Lisa B., Jäättelä, Marja, Locatelli, Franco, Barisic, Marin, Andersen, Jens S., Bekker-Jensen, Simon, Lund, Anders H., Rogov, Vladimir V., Papaleo, Elena, Lanzetti, Letizia, De Zio, Daniela, Cecconi, Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744468/
https://ncbi.nlm.nih.gov/pubmed/31519908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12094-9
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