Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites

The centrosome is the master orchestrator of mitotic spindle formation and chromosome segregation in animal cells. Centrosome abnormalities are frequently observed in cancer, but little is known of their origin and about pathways affecting centrosome homeostasis. Here we show that autophagy preserve...

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Publicat a:Nat Commun
Autors principals: Holdgaard, Søs Grønbæk, Cianfanelli, Valentina, Pupo, Emanuela, Lambrughi, Matteo, Lubas, Michal, Nielsen, Julie C., Eibes, Susana, Maiani, Emiliano, Harder, Lea M., Wesch, Nicole, Foged, Mads Møller, Maeda, Kenji, Nazio, Francesca, de la Ballina, Laura R., Dötsch, Volker, Brech, Andreas, Frankel, Lisa B., Jäättelä, Marja, Locatelli, Franco, Barisic, Marin, Andersen, Jens S., Bekker-Jensen, Simon, Lund, Anders H., Rogov, Vladimir V., Papaleo, Elena, Lanzetti, Letizia, De Zio, Daniela, Cecconi, Francesco
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744468/
https://ncbi.nlm.nih.gov/pubmed/31519908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12094-9
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