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Gata4基因H435Y突变型小鼠模型的建立及验证
OBJECTIVE: To establish a mouse model of H435Y mutation of Gata4 gene using CRISPR/Cas9- mediated gene targeting. METHODS: The single-stranded guide RNA (sgRNA) specific to the H435Y loci of Gata4 gene was designed based on the sequence of Gata4 gene. After activity assessment, the active sgRNA and...
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| Pubblicato in: | Nan Fang Yi Ke Da Xue Xue Bao |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
南方医科大学学报编辑部
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6744054/ https://ncbi.nlm.nih.gov/pubmed/30377126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3969/j.issn.1673-4254.2018.10.15 |
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