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Executable pathway analysis using ensemble discrete-state modeling for large-scale data
Pathway analysis is widely used to gain mechanistic insights from high-throughput omics data. However, most existing methods do not consider signal integration represented by pathway topology, resulting in enrichment of convergent pathways when downstream genes are modulated. Incorporation of signal...
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| Udgivet i: | PLoS Comput Biol |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6743792/ https://ncbi.nlm.nih.gov/pubmed/31479446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007317 |
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