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Deconvolving multiplexed protease signatures with substrate reduction and activity clustering

Proteases are multifunctional, promiscuous enzymes that degrade proteins as well as peptides and drive important processes in health and disease. Current technology has enabled the construction of libraries of peptide substrates that detect protease activity, which provides valuable biological infor...

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Bibliografski detalji
Izdano u:PLoS Comput Biol
Glavni autori: Zhuang, Qinwei, Holt, Brandon Alexander, Kwong, Gabriel A., Qiu, Peng
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6743790/
https://ncbi.nlm.nih.gov/pubmed/31479443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006909
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