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Synergistic inhibition of MEK and reciprocal feedback networks for targeted intervention in malignancy
The RAS-RAF-MEK-ERK signaling pathway (MAPK signaling pathway) plays a significant role in multiple pathological behaviors and is most frequently dysregulated in more than 30% of human cancers. As key elements in this pathway, MEK1/2 play crucial roles in tumorigenesis and the inhibition of apoptosi...
Αποθηκεύτηκε σε:
Τόπος έκδοσης: | Cancer Biol Med |
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Κύριοι συγγραφείς: | , , |
Μορφή: | Artigo |
Γλώσσα: | Inglês |
Έκδοση: |
Chinese Anti-Cancer Association
2019
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Θέματα: | |
Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6743629/ https://ncbi.nlm.nih.gov/pubmed/31565475 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.20892/j.issn.2095-3941.2019.0137 |
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