Lowe syndrome–linked endocytic adaptors direct membrane cycling kinetics with OCRL in Dictyostelium discoideum

Mutations of the inositol 5-phosphatase OCRL cause Lowe syndrome (LS), characterized by congenital cataract, low IQ, and defective kidney proximal tubule resorption. A key subset of LS mutants abolishes OCRL’s interactions with endocytic adaptors containing F&H peptide motifs. Converging unbiase...

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Publicado en:Mol Biol Cell
Autores principales: Luscher, Alexandre, Fröhlich, Florian, Barisch, Caroline, Littlewood, Clare, Metcalfe, Joe, Leuba, Florence, Palma, Anita, Pirruccello, Michelle, Cesareni, Gianni, Stagi, Massimiliano, Walther, Tobias C., Soldati, Thierry, De Camilli, Pietro, Swan, Laura E.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Cell Biology 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6743453/
https://ncbi.nlm.nih.gov/pubmed/31216233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E18-08-0510
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