Melatonin Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib through the PERK-ATF4-Beclin1 Pathway

The mechanisms of resistance to the targeted drug sorafenib in the treatment of hepatocellular carcinoma (HCC) are poorly understood. The purpose of this study was to investigate the mechanism of sorafenib resistance and to elucidate the role of melatonin in overcoming sorafenib resistance. We first...

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Bibliographische Detailangaben
Veröffentlicht in:Int J Biol Sci
Hauptverfasser: Zhou, Bei, Lu, Qianqian, Liu, Jiatao, Fan, Lulu, Wang, Yu, Wei, Wei, Wang, Hua, Sun, Guoping
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2019
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6743299/
https://ncbi.nlm.nih.gov/pubmed/31523192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.32550
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